Research Cores Updates

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The Advanced Imaging Core (AIC) is running a REDUCED FEE SPECIAL OFFER THROUGH THE END OF MAY:

The AIC’s consultation fee to use the new Zeiss Elyra 7 Super-Resolution microscope has been reduced to $80* till the end of May! On June 1st, 2021, the consultation fee will increase to $100*.

Using the same essential sample preparation as confocal microscopy, Lattice SIM (Structured Illumination Microscopy) technology offers double the resolving power (up to 120nm in xy and 300 nm in z) in both fixed and live samples. The Elyra 7 is also capable of SMLM (Single-Molecule Localization Microscopy) techniques, including dSTORM and PALM. With SMLM, photo-switchable fluorescent proteins and dyes are excited with a high-power laser in the presence of an oxygen-scavenging buffer. The result: instead of photo-bleaching the sample, the fluorophores switch back and forth between an “On” and “Off” state, creating “blinks”. Capturing these individual blinks in a time series, the Elyra system can reconstruct an image with a resolution of 20nm in xy and 50nm in z!

Visit the AIC webpage to become familiar with recommended sample preparation protocols, then go to iLab to reserve an AIC consultation time.

Contact Dr. Rachel Escue Helms, AIC Microscopy Manager, at 901.448.6180 or rescue@uthsc.edu .

*Cost of consultation will be credited towards your first experiment.


Register now for the annual Southeastern Association of Shared Resources meeting:

The 2021 Annual Southeastern Association of Shared Resources (SEASR) meeting is June 10-11th. This year, the event will be completely virtual. The program features a strong lineup of speakers and topics that should be of interest to core staff and others.  Registration is FREE, but closes early June. Register now!  

Dr. Tiffany Seagroves, AVC of UTHSC’s Institutional Research Cores, is president-elect of SEASR, and UTHSC is a gold institutional sponsor of this event. Contact her with any questions at  tseagro1@uthsc.edu or 901.448.5018.


Shared Resources Technology Talks:

This year, the Cores started a new presentation series, Shared Resources Technology Talks. Presentations this spring have included “Development and implementation of clinical proteomics for precision oncology applications and therapeutic drug development” and “An investigative metabolomics and lipidomics study on the Thermo Scientific Orbitrap Exploris 240 Mass Spectrometer.”  A new webpage containing recordings of Shared Resources Technology Talk presentations can be accessed here.


Hot Topics in Research will be coming again soon:

Hot Topics in Research, the educational lunch-and-learn series about opportunities and resources available to the UTHSC research community, will be returning this fall!  Individual Research Cores have been featured in the past, and will be part of the upcoming lineup. If there is a Core you would like to learn more about, please let us know!  Contact Lee Ferguson at lfergu12@uthsc.edu with your talk suggestions. In the meantime, past Hot Topics presentations can be viewed on the Office of Research webpage. Stay tuned for the fall lineup!

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